Authors:
M. N. Drozd
Ural State Agrarian University, Ekaterinburg, Russia *E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Abstract. Modern conditions of animal husbandry and poultry farming dictate a continuous search for effective means that increase the natural resistance of the organism of farm animals and poultry. The purpose of the study. In this regard, an experimental study was conducted on laboratory animals using a mineral adaptogen of domestic production in order to determine its effectiveness in conditions of artificially induced immunosuppression. The objectives of the study were to determine the immunobiochemical status, subcellular and intra-organ changes in the organs of the immune system at all levels. Research methods. Experimental studies were carried out using generally accepted zootechnical, pathomorphological, histological, immunobiochemical and statistical research methods. Results. Immunobiochemical changes in the body of experimental animals are described. Microscopic changes at the level of tissues and cells in the organs of the immune system at all levels are described. Changes in the organs of the immune system during immunosuppression and against the background of feeding mineral adaptogen are described. Morphological examination of the immune system organs in experimental animals revealed prolonged immunosuppressive changes for 14 days. At the same time, after induced immunosuppression, significant structural changes remain in the central and peripheral organs of the immune system in the form of lymphoid tissue atrophy (in the thymus, both in the organ of central immunogenesis and in the organs of the peripheral immune system – the spleen and lymph nodes and intra-organ lymph formations). During histological studies, the structure of cells and tissues, when using a mineral adaptogen, was more morphologically mature and was in a functionally active state, and dystrophic and necrotic processes were observed in the control group. The conducted studies convincingly prove the effect of mineral adaptogen on increasing natural resistance and its immunoprotective properties. Scientific novelty. For the first time in experimental conditions, a simultaneous assessment of the immunobiochemical parameters of the blood of laboratory animals and a microscopic examination of the organs of the immune system at all levels with morphometric analysis of the data obtained were given. As a result of the conducted studies, the immunoand organoprotective effect of feeding the mineral adaptogen was proved and the immunomodulatory effect was morphometrically confirmed.
Keywords: adaptogens, morphometry, histology, immune system organs, blood immunology, blood biochemistry, respiratory organs, immunocompetent system.
For citation: Drozd M. N. Effektivnost’ mineral’nogo adaptogena v usloviyakh eksperimental'noy immunosupressii [The effectiveness of mineral adaptogen in experimental immunosuppression] // Agrarian Bulletin of the Urals. 2021. No. 12 (215). Pp. 29–40. DOI: 10.32417/1997-4868-2021-215-12-29-40. (In Russian.)
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