P. V. Burkov1 , M. B. Rebezov2, 3, M. A. Derkho1 , P. N. Shcherbakov1 , A. O. Derkho1
1 South Ural State Agrarian University, Troitsk, Russia
2 V. M. Gorbatov Federal Scientific Center for Food Systems of the Russian Academy of Sciences, Moscow, Russia
3 Ural State Agrarian University, Ekaterinburg, Russia E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Volume 25 No. 7
Date of paper submitted: 21.05.2025, date of review: 05.06.2025, date of acceptance: 11.06.2025.
Published: 07/31/2025
Annotation. The purpose of the research was to study histopathological changes in tendons, bone-tendon joints and vertebrae of pigs with a clinically pronounced form of circovirus infection. Methods and methodology. Tissue samples of the musculoskeletal system were used for histopathological studies. They are obtained from pigs euthanized for diagnostic purposes. The tissue samples were fixed in 10 % neutral buffered formalin, treated as standard and embedded in paraffin wax. Sections with a thickness of 5 microns were made from tissue samples on a MS-2 sledge microtome (Russia), stained with hematoxylin and eosin, and examined using a Leica DMRXA microscope. The photos of the histological sections were obtained using a Leica DFC 290 camera. Results. Microscopic studies of the components of the musculoskeletal system of pigs show that pathological changes form in the tendons, bone-tendon joints and vertebrae associated with the circulation of the CVV2 virus in their body. The histological picture of the studied samples is characterized by the presence of degenerative and dystrophic changes. They are complicated by tendinosis due to degenerative changes in tendons and secondary tendonitis of traumatic origin, as evidenced by small hemorrhages in the peritendinia and fields of macrophage infiltration of tendon fibers. Changes in the tissues of the musculoskeletal system develop as a result of the absence of an adequate immune response in pigs to vaccination against CVS 2 and can be considered as one of the manifestations of CVS 2 infection in pigs. Scientific novelty. For the first time, it has been shown that the pathological process of circovirus infection involves components of the musculoskeletal system of pigs (tendons, bone-tendon joints, vertebrae), in which degenerative-dystrophic changes occur according to the type of osteochondrosis.
Keywords: circovirus infection, piglets, histopathology, tendons, bone-tendon joints, vertebrae
Acknowledgements. The publication was prepared as part of the implementation of the scientific project of the Russian Science Foundation (Agreement No. 22-16-20007 dated 03/25/2022).
For citation: Burkov P. V., Rebezov M. B., Derkho M. A., Shcherbakov P. N., Derkho A. O. Microscopic features of the components of the musculoskeletal system in piglets with type 2 circovirus infection. Agrarian Bulletin of the Urals. 2025; 25 (07): 1060‒1073. https://doi.org/10.32417/1997-4868-2025-25-07-1060-1073 (In Russ.)
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