Authors:
N. V. FEDOTA, candidate of veterinary sciences, associate professor,
E. A. FONAREVA, assistant veterinarian ND I LVC,
Stavropol State Agrarian University (12 Zootehnicheskij l., 523 Serova str., 355000, Stavropol).
Abstract. The problem of healing wounds of various etiologies does not lose its relevance for many decades. The basic methodology for solving this problem is the principle of managing the wound process by directing local action on it with biologically active substances with antimicrobial activity. In the development of these aspects, the achievements of modern pharmacology are of undoubted interest, allowing the development of new drugs that have the property of resisting the development of infectious complications in the wound and improving tissue repair without adversely affecting the body. According to many authors and scientists who studied the processes of regeneration of wounds of various etiologies under experimental conditions, the advantages of using drugs with antimicrobial effect are proved. Inclusion of silver and zinc in nanoparticles leads to a less pronounced inflammatory process in the focus, which is a morphological substrate for the formation of granulations in the trauma. Silver has a wide spectrum of antimicrobial activity against aerobic and anaerobic microflora, including antibiotic-resistant microflora; shows virucidal and fungicidal activity; has anti-inflammatory effect. Zinc compounds are one of the components of a number of complex dermatological and cosmetic preparations, such as «Zinc Ointment», «Pasta Lassara», etc. Their pharmacological action consists in the formation of albumin and protein denaturation. When applied to the affected surface, the processes of exudation, inflammation and irritation of tissues decrease. The ability of zinc to participate in ligand formation with organic molecules explains the extremely wide range of its participation in different biological systems. This is accompanied by the relative safety of this element, especially the lack of oxidative properties (unlike iron and copper), which improves the transport and metabolism of zinc in the body and promotes rapid assimilation by its cells. Zinc-dependent are such vital hormones as insulin, corticotropin, somatotropin, gonadotropins, it is necessary for the formation of erythrocytes and other blood elements. It is believed that zinc has antioxidant properties, and also improves the effect of other antioxidants. In the study, it was shown that the use of a preparation based on silver and zinc nanoparticles leads to an intensification of eviction into the damage area of cellular elements with a simultaneous increase in their functional activity.
Keywords: histomorphological changes, ointment with nanoparticles, regenerating properties, inflammation.
