Authors:
L. I. DROZDOVA,
doctor of veterinary sciences, professor, head of department, Ural State Agrarian University
(42 K. Libknehta Str., 620075, Ekaterinburg),
E. A. REUTOVA,
candidate of veterinary sciences, associate professor, Novosibirsk State Agrarian University
(160 Dobrolyubova Str., 630039, Novosibirsk; e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.),
N. V. SADOVNIKOV,
doctor of veterinary sciences, professor, Ural State Agrarian University
(42 K. Libknehta Str., 620075, Ekaterinburg)
Abstract. The paper presents material on the manifestation of the morphological reaction of the liver of piglets after the application of nucleic nature “Westin” in the system “мother-fetus”. The liver is one of the main organs that support homeostasis in mammals, participates in all kinds of metabolism and is the most suitable object for studying general and particular problems of the influence of drugs. During pregnancy, as well as in the period of early postnatal development, changes in the liver can occur that are necessary for energy supply and maintenance of the organism’s vitality. The studies were performed on sows of large white breed and the piglets from 10 daily to 7 months of age. For histological examination samples of the liver of the piglets were recorded in the 10–12 % solution of neutral formalin was poured into the wax, preparing the sections with thickness of 5–7 μm and stained by classical methods of morphological research. In sections of liver was carried out morphometric studies. In the liver of piglets of the experimental group noted the change of immunomorphological reactions in the form of the accumulation of lymphoid cells in the region of the triads by the type of follicle. A pronounced symptom of the liver of pigs of the control group was the growth of connective tissue capsule and region of the triad due to the increase in the number and hypertrophy of cells reticulohistiocytoma system. Histochemical analysis of hepatocytes of the liver of newborn piglets, showed lipid inclusions and the presence of uniformly and densely arranged in the central portions of the cells of granules of glycogen both in the center and the periphery of the lobules, the presence of intense staining for RNA, the intensity of such staining in the cytoplasm of hepatocytes of piglets of the control group was visually somewhat reduced and represented by small granules. It is shown a positive effect of test drug on the morphological structure of the liver of pigs and the formation of adaptive reactions of the organism. The drug is the “Westin” with the introduction of the system “мother-fetus” in the later stages of fruiting, has a positive influence on the content of glycogen and RNA in the hepatocytes of the liver of pigs that is characterized by a high level of energy and plastic processes.
Keywords: adaptation, immunocorrection, morphologic reaction, liver, hepatocyte, piglets, “mother-fetus” system, nucleic preparation.
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